NAD+-Consuming Enzymes in Stem Cell Homeostasis

Oxid Med Cell Longev. 2023 Feb 8;2023:4985726. doi: 10.1155/2023/4985726. eCollection 2023.


Nicotinamide adenine dinucleotide (NAD+) is a coenzyme used in redox reactions, energy metabolism, and mitochondrial biogenesis. NAD+ is also required as a cofactor by nonredox NAD+-dependent enzymes. Hundreds of enzymes that consume NAD+ have been identified. The NAD+-consuming enzymes are involved in a variety of cellular processes such as signal transduction, DNA repair, cellular senescence, and stem cell (SC) homeostasis. In this review, we discussed how different types of NAD+-consuming enzymes regulate SC functions and summarized current research on the roles of the NAD+ consumers in SC homeostasis. We hope to provide a more global and integrative insight to the mechanism and intervention of SC homeostasis via the regulation of the NAD+-consuming enzymes.

Publication types

  • Review

MeSH terms

  • Energy Metabolism*
  • Homeostasis
  • NAD* / metabolism
  • Oxidation-Reduction
  • Signal Transduction


  • NAD