Fatal Case of Heartland Virus Disease Acquired in the Mid-Atlantic Region, United States

Emerg Infect Dis. 2023 May;29(5):992-996. doi: 10.3201/eid2905.221488. Epub 2023 Feb 23.


Heartland virus (HRTV) disease is an emerging tickborne illness in the midwestern and southern United States. We describe a reported fatal case of HRTV infection in the Maryland and Virginia region, states not widely recognized to have human HRTV disease cases. The range of HRTV could be expanding in the United States.

Keywords: Heartland virus; United States; Virginia; emerging infections; hemophagocytic lymphohistiocytosis; mid-Atlantic; parasites; tick-borne illness; vector-borne infections; viruses; zoonoses.

MeSH terms

  • Bunyaviridae Infections* / diagnosis
  • Humans
  • Mid-Atlantic Region
  • Phlebovirus* / genetics
  • United States / epidemiology
  • Virus Diseases*

Supplementary concepts

  • Heartland virus