Mendelian Randomization Studies in Psoriasis and Psoriatic Arthritis: A Systematic Review

J Invest Dermatol. 2023 May;143(5):762-776.e3. doi: 10.1016/j.jid.2022.11.014. Epub 2023 Feb 22.


Psoriasis (PSO) and psoriatic arthritis (PSA) are inflammatory diseases with complex genetic and environmental contributions. Although studies have identified environmental and clinical associations with PSO/PSA, causality is difficult to establish. Mendelian randomization (MR) employs the random assortment of genetic alleles at birth to evaluate the causal impact of exposures. We systematically reviewed 27 MR studies in PSO/PSA examining health behaviors, comorbidities, and biomarkers. Exposures, including smoking, obesity, cardiovascular disease, and Crohn's disease, were causal for PSO and PSA, whereas PSO was causally associated with several comorbidities. These findings provide insights that can guide preventive counseling and precision medicine.

Publication types

  • Systematic Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arthritis, Psoriatic* / complications
  • Arthritis, Psoriatic* / epidemiology
  • Arthritis, Psoriatic* / genetics
  • Biomarkers
  • Comorbidity
  • Humans
  • Infant, Newborn
  • Mendelian Randomization Analysis
  • Psoriasis* / complications
  • Psoriasis* / epidemiology
  • Psoriasis* / genetics


  • Biomarkers