Primary central nervous system lymphoma: a practical guide for neurologists

Pract Neurol. 2023 Aug;23(4):286-292. doi: 10.1136/pn-2022-003656. Epub 2023 Feb 23.

Abstract

Primary central nervous system lymphoma is rare, comprising 4% of intracranial neoplasms. Although haematologists or oncologists subsequently manage the condition, it is often neurologists who first make, or at least suspect, the diagnosis. This article reviews the disease, its clinical and radiological features and details the work-up needed to achieve a diagnosis (namely histological or cytological confirmation) and to prepare the patient for treatment. We note the importance of brain biopsy, the role of corticosteroids and the varied treatment options.

Keywords: CLINICAL NEUROLOGY; HAEMATOLOGY; LYMPHOMA; NEUROONCOLOGY; STEROIDS.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones
  • Brain Neoplasms* / diagnosis
  • Central Nervous System
  • Humans
  • Lymphoma* / diagnosis
  • Lymphoma* / pathology
  • Lymphoma* / therapy
  • Neurologists

Substances

  • Adrenal Cortex Hormones