Early and post-treatment imaging findings in perineural spread: a pathway to diffuse muscle metastasis in recurrent bladder carcinoma

Yoshimitsu Honda; Tetsuro Sekine; Ryoji Kimata; Norio Motoda; Keigo Takahashi; Aya Yamane; Daisuke Yasui; Eigo Kodani; Taro Ichikawa; Shinichiro Kumita

doi:10.1272/jnms.JNMS.2024_91-301

Early and post-treatment imaging findings in perineural spread: a pathway to diffuse muscle metastasis in recurrent bladder carcinoma

J Nippon Med Sch. 2023 Feb 21. doi: 10.1272/jnms.JNMS.2024_91-301. Online ahead of print.

Authors

Affiliations

¹ Department of Radiology, Nippon Medical School.
² Department of Radiology, Nippon Medical School Musashi Kosugi Hospital.
³ Department of Urology, Nippon Medical School Musashi Kosugi Hospital.
⁴ Department of Diagnostic Pathology, Nippon Medical School Musashi Kosugi Hospital.

PMID: 36823118
DOI: 10.1272/jnms.JNMS.2024_91-301

Abstract

Perineural spread (PNS) from pelvic carcinoma has been regarded as a pathway to muscle and bone metastasis. However, few cases have been reported, especially in patients with bladder carcinoma. In the present report, we discuss a case of diffuse cancer involvement in the muscle 5 years after radical cystectomy for advanced bladder carcinoma. Careful observation of temporal changes on medical images confirmed PNS as the pathway to muscle metastasis (i.e., primary PNS). Our report presents early and post-treatment CT, MRI and FDG-PET/CT findings of PNS from the bladder carcinoma.

Keywords: MRI; PET/CT; bladder carcinoma; muscle metastasis; perineural spread.