The association between patterns of early respiratory disease and diastolic dysfunction in preterm infants

J Perinatol. 2023 Oct;43(10):1268-1273. doi: 10.1038/s41372-023-01608-5. Epub 2023 Feb 23.

Abstract

Background: This study aims to determine the association between clinical patterns of early respiratory disease and diastolic dysfunction in preterm infants.

Methods: Preterm infants <29 weeks' gestation underwent cardiac ultrasounds around day 7 and 14-21. Respiratory dysfunction patterns were classified as stable (ST), respiratory deterioration (RD) or early persistent respiratory dysfunction (EPRD) according to oxygen need. Diastolic dysfunction was diagnosed using a multi-parameter approach including left atrial strain (LASR) to help differentiate between cardiac or pulmonary pathophysiology.

Results: 98 infants (mean 27 weeks) were included. The prevalence of ST, RD and EPRD was 53%, 21% and 26% respectively. Diastolic dysfunction was more prevalent in the RD and EPRD groups with patent ductus arteriosus and significant growth restriction as risk factors. Not all infants with a PDA developed diastolic dysfunction. LASR was lower in the EPDR group.

Conclusion: Respiratory dysfunction patterns are associated with diastolic dysfunction in preterm infants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ductus Arteriosus, Patent* / complications
  • Ductus Arteriosus, Patent* / diagnostic imaging
  • Ductus Arteriosus, Patent* / epidemiology
  • Gestational Age
  • Humans
  • Ibuprofen / adverse effects
  • Infant
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Infant, Premature
  • Respiratory Tract Diseases*

Substances

  • Ibuprofen