Translating energy balance research from the bench to the clinic to the community: Parallel animal-human studies in cancer

Miriam B Garcia; Keri L Schadler; Joya Chandra; Steven K Clinton; Kerry S Courneya; Zobeida Cruz-Monserrate; Carrie R Daniel; Andrew J Dannenberg; Wendy Demark-Wahnefried; Mark W Dewhirst; Carol J Fabian; Stephen D Hursting; Melinda L Irwin; Neil M Iyengar; Jennifer L McQuade; Kathryn H Schmitz; Karen Basen-Engquist

doi:10.3322/caac.21773

Translating energy balance research from the bench to the clinic to the community: Parallel animal-human studies in cancer

CA Cancer J Clin. 2023 Jul-Aug;73(4):425-442. doi: 10.3322/caac.21773. Epub 2023 Feb 24.

Authors

Miriam B Garcia¹, Keri L Schadler², Joya Chandra², Steven K Clinton³, Kerry S Courneya⁴, Zobeida Cruz-Monserrate⁵, Carrie R Daniel⁶, Andrew J Dannenberg⁷, Wendy Demark-Wahnefried⁸, Mark W Dewhirst⁹, Carol J Fabian¹⁰, Stephen D Hursting¹¹, Melinda L Irwin¹², Neil M Iyengar¹³, Jennifer L McQuade¹⁴, Kathryn H Schmitz¹⁵, Karen Basen-Engquist¹⁶

Affiliations

¹ Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
² Department of Pediatrics-Research, The University of Texas MD Anderson Cancer Center, Texas, Houston, USA.
³ Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.
⁴ Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Alberta, Canada.
⁵ Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.
⁶ Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
⁷ Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
⁸ Department of Nutrition Sciences, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
⁹ Department of Radiation Oncology, Duke University School of Medicine, Durham, North Carolina, USA.
¹⁰ Department of Medicine, Division of Medical Oncology, The University of Kansas Medical Center, Westwood, Kansas, USA.
¹¹ Department of Nutrition Sciences, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
¹² Department of Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA.
¹³ Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
¹⁴ Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
¹⁵ Division of Hematology and Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
¹⁶ Department of Health Disparities Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Abstract

Advances in energy balance and cancer research to date have largely occurred in siloed work in rodents or patients. However, substantial benefit can be derived from parallel studies in which animal models inform the design of clinical and population studies or in which clinical observations become the basis for animal studies. The conference Translating Energy Balance from Bench to Communities: Application of Parallel Animal-Human Studies in Cancer, held in July 2021, convened investigators from basic, translational/clinical, and population science research to share knowledge, examples of successful parallel studies, and strong research to move the field of energy balance and cancer toward practice changes. This review summarizes key topics discussed to advance research on the role of energy balance, including physical activity, body composition, and dietary intake, on cancer development, cancer outcomes, and healthy survivorship.

Keywords: body composition; cancer; cancer survivorship; diet; exercise; nutrition; translational research.

Translating energy balance research from the bench to the clinic to the community: Parallel animal-human studies in cancer

Authors

Affiliations

Abstract

Publication types

MeSH terms

Grants and funding