Non-small cell lung cancer (NSCLC): A review of risk factors, diagnosis, and treatment

Medicine (Baltimore). 2023 Feb 22;102(8):e32899. doi: 10.1097/MD.0000000000032899.


Lung cancer remains the leading cause of cancer deaths. Non-small cell lung cancer (NSCLC) is the most frequent subtype of lung cancer. Surgery, radiation, chemotherapy, immunotherapy, or molecularly targeted therapy is used to treat NSCLC. Nevertheless, many patients who accept surgery likely develop distant metastases or local recurrence. In recent years, targeted treatments and immunotherapy have achieved improvement at a breakneck pace. Therapy must be customized for each patient based on the specific medical condition, as well as other variables. It is critical to have an accurate NSCLC sub-classification for tailored treatment, according to the latest World Health Organization standards.

Publication types

  • Review

MeSH terms

  • Carcinoma, Non-Small-Cell Lung* / drug therapy
  • Combined Modality Therapy
  • Humans
  • Immunotherapy
  • Lung Neoplasms* / pathology
  • Risk Factors