Macrophages and bone metastasis

J Exp Med. 2023 Apr 3;220(4):e20222188. doi: 10.1084/jem.20222188. Epub 2023 Feb 24.


In the prostate bone metastasis microenvironment, macrophages activate a cascade that involves Activin A, the extracellular matrix, and SRC kinase and drives resistance to anti-androgen therapy. These findings (Li et al., 2023. J. Exp. Med. have broad implications, including metastasis diversity in different tissue milieus and the interplay between hormones and immunity.

Publication types

  • Comment

MeSH terms

  • Bone Neoplasms*
  • Humans
  • Macrophages*
  • Male
  • Tumor Microenvironment