Metastasis of endometrial cancer to breast: A rare case

J Obstet Gynaecol Res. 2023 May;49(5):1452-1455. doi: 10.1111/jog.15621. Epub 2023 Feb 24.


Only 2% of all breast cancers are metastatic, making them extremely uncommon. They are frequently mistaken for a primary breast tumor. Although it has been observed, metastatic spread from primary uterine cancers is extremely uncommon. In the literature, our case represents the fourth endometroid adenocarcinoma metastasis from the uterus. Clinical, pathological, and immunohistochemical examination and management of metastatic endometrioid adenocarcinoma of the uterus' extragenital organ were described in this 69-year-old patient's case. Immunohistochemical analysis was performed on a breast biopsy taken from the patient who underwent therapy and discovered a breast mass two years later. Metastatic endometrial adenocarcinoma was diagnosed with negative signs pointing to mammaglobin, GCDFP-15 and GATA3 breasts and markers indicating endometroid adenocarcinomas such as p53, PAX8 and VIMENTIN support. As a result, a thorough clinical history is needed, with special attention to diagnoses of concurrent or prior malignancies, along with clinical examination, appropriate radiological evaluation, and immunohistochemistry. This is necessary to prevent unnecessary surgery, to provide appropriate systemic treatment, to ensure correct diagnosis, and to manage treatment.

Keywords: breast metastasis; endometrial cancer; gynecologic oncology.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma* / pathology
  • Aged
  • Biomarkers, Tumor
  • Breast Neoplasms* / diagnosis
  • Carcinoma*
  • Endometrial Neoplasms*
  • Female
  • Humans


  • Biomarkers, Tumor