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Review
. 2023 Jun;24(3):329-346.
doi: 10.1007/s10522-023-10020-7. Epub 2023 Feb 25.

Roles of genistein in learning and memory during aging and neurological disorders

Vijay Paramanik  1 , Khuleshwari Kurrey  2 , Padmanabh Singh  3 , Sneha Tiwari #  3 , Nisha #  3
Affiliations
Review

Roles of genistein in learning and memory during aging and neurological disorders

Vijay Paramanik et al. Biogerontology. 2023 Jun.

Abstract

Genistein (GEN) is a non-steroidal phytoestrogen that belongs to the isoflavone class. It is abundantly found in soy. Soy and its products are used as food components in many countries including India. The present review is focused to address roles of GEN in brain functions in the context of learning and memory as a function of aging and neurological disorders. Memory decline is one of the most disabling features observed during normal aging and age-associated neurodegenerative disorders namely Alzheimer's disease (AD) and Parkinson's disease (PD), etc. Anatomical, physiological, biochemical and molecular changes in the brain with advancement of age and pathological conditions lead to decline of cognitive functions. GEN is chemically comparable to estradiol and binds to estrogen receptors (ERs). GEN acts through ERs and mimics estrogen action. After binding to ERs, GEN regulates a plethora of brain functions including learning and memory; however detailed study still remains elusive. Due to the neuroprotective, anti-oxidative and anti-inflammatory properties, GEN is used to restore or improve memory functions in different animal models and humans. The present review may be helpful to understand roles of GEN in learning and memory during aging and neurological disorders, its direction of research and therapeutic perspectives.

Keywords: Aging; Estrogen; Genistein; Learning and memory; Neurological disorders.

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