Co-Translational Quality Control Induced by Translational Arrest

Biomolecules. 2023 Feb 7;13(2):317. doi: 10.3390/biom13020317.


Genetic mutations, mRNA processing errors, and lack of availability of charged tRNAs sometimes slow down or completely stall translating ribosomes. Since an incomplete nascent chain derived from stalled ribosomes may function anomalously, such as by forming toxic aggregates, surveillance systems monitor every step of translation and dispose of such products to prevent their accumulation. Over the past decade, yeast models with powerful genetics and biochemical techniques have contributed to uncovering the mechanism of the co-translational quality control system, which eliminates the harmful products generated from aberrant translation. We here summarize the current knowledge of the molecular mechanism of the co-translational quality control systems in yeast, which eliminate the incomplete nascent chain, improper mRNAs, and faulty ribosomes to maintain cellular protein homeostasis.

Keywords: mRNA decay; non-canonical ribosome dissociation; protein degradation; quality control; ribosome collision; transrational arrest; ubiquitination.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Protein Biosynthesis*
  • RNA, Transfer / metabolism
  • Ribosomes / metabolism
  • Saccharomyces cerevisiae* / metabolism


  • RNA, Transfer

Grants and funding

This work was supported by JST PREST grant number JPMJPR21EE to Y.M. and by MEXT/JSPS KAKENHI grant number 21H05710, 21H00267, 22H02606 to Y.M. This work was supported by AMED grant number JP20gm1110010 (T.I.), MEXT/JSPS KAKENHI grant numbers 19H05281, 21H05277, 22H00401 (T.I.), and research grants from the Takeda Science Foundation (T.I.).