The Role of CD38 in the Pathogenesis of Cardiorenal Metabolic Disease and Aging, an Approach from Basic Research

Munehiro Kitada; Shin-Ichi Araki; Daisuke Koya

doi:10.3390/cells12040595

The Role of CD38 in the Pathogenesis of Cardiorenal Metabolic Disease and Aging, an Approach from Basic Research

Cells. 2023 Feb 12;12(4):595. doi: 10.3390/cells12040595.

Authors

Munehiro Kitada^{1

2}, Shin-Ichi Araki², Daisuke Koya^{3

4}

Affiliations

¹ Department of Internal Medicine, Hamada Neurosurgery and Internal Medicine Clinic, Wakayama 641-8509, Japan.
² Department of Nephrology, Wakayama Medical University, Wakayama 641-8509, Japan.
³ Omi Medical Center, Kusatsu, Shiga 525-8585, Japan.
⁴ Division of Anticipatory Molecular Food Science and Technology, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan.

Abstract

Aging is a major risk factor for the leading causes of mortality, and the incidence of age-related diseases including cardiovascular disease, kidney disease and metabolic disease increases with age. NAD⁺ is a classic coenzyme that exists in all species, and that plays a crucial role in oxidation-reduction reactions. It is also involved in the regulation of many cellular functions including inflammation, oxidative stress and differentiation. NAD⁺ declines with aging in various organs, and the reduction in NAD⁺ is possibly involved in the development of age-related cellular dysfunction in cardiorenal metabolic organs through the accumulation of inflammation and oxidative stress. Levels of NAD⁺ are regulated by the balance between its synthesis and degradation. CD38 is the main NAD⁺-degrading enzyme, and CD38 is activated in response to inflammation with aging, which is associated with the reduction in NAD⁺ levels. In this review, focusing on CD38, we discuss the role of CD38 in aging and the pathogenesis of age-related diseases, including cardiorenal metabolic disease.

Keywords: CD38; NAD+; aging; cardiovascular disease; kidney disease; metabolic disease.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

ADP-ribosyl Cyclase 1* / metabolism
Aging* / metabolism
Aging* / pathology
Humans
Inflammation
Metabolic Diseases* / metabolism
Metabolic Diseases* / pathology
NAD / metabolism

Substances

ADP-ribosyl Cyclase 1
NAD
CD38 protein, human

Grants and funding

This research was funded by KAKENHI, Grant-in-Aid for Challenging Exploratory Research 20K21773 to D.K., and KAKENHI, Grant-in-Aid for Scientific Research (C) 21K08290 to M.K.