Comparison between pre- and post-contrast cardiac MRI cine images: the impact on ventricular volume and strain measurement

Int J Cardiovasc Imaging. 2023 May;39(5):1055-1064. doi: 10.1007/s10554-023-02809-x. Epub 2023 Feb 25.


To explore whether contrast agent administration will affect ventricular volume and strain parameters measured on cardiac magnetic resonance cine images. This prospective study enrolled 88 patients, including 32 patients with cardiac amyloidosis (CA), 32 patients with hypertrophic cardiomyopathy (HCM), and 24 control participants, to perform steady-state free precession (SSFP)-cine imaging twice, respectively before and after contrast agent injection. Indexed left and right ventricular (LV and RV) volume and LV strain parameters (peak radial strain [PRS], peak circumferential strain [PCS], peak longitudinal strain [PLS]) were analyzed and compared between the pre- and post-contrast cine groups. Compared to the group of pre-contrast cine, the end-diastolic volume index (EDVi) and end-systolic volume index (ESVi) significantly increased in the group using post-contrast cine images (all p < 0.05), especially in the right ventricle. After contrast injection, the right ventricular ejection fraction (RVEF) decreased significantly (p < 0.05), while the left ventricular ejection fraction (LVEF) only reduced for patients with HCM (p < 0.05). The PRS (37.1 ± 15.2 vs. 32.0 ± 15.4, p < 0.001) and PCS (- 14.9 ± 4.3 vs. - 14.0 ± 4.1, p < 0.001) derived from post-contrast cine images reduced significantly in all patients and this tendency remained in subgroup analysis except for PCS in the control group. The administration of a contrast agent may influence the measurements of ventricular volume and strain. Acquiring pre-contrast cine images were suggested for patients who required more accurate right ventricle evaluation or precise strain assessment.

Keywords: Cardiac magnetic resonance; Cine imaging; Contrast agent; Strain; Ventricular volume.

MeSH terms

  • Contrast Media*
  • Heart Ventricles / diagnostic imaging
  • Humans
  • Magnetic Resonance Imaging
  • Magnetic Resonance Imaging, Cine / methods
  • Predictive Value of Tests
  • Prospective Studies
  • Stroke Volume
  • Ventricular Function, Left*
  • Ventricular Function, Right


  • Contrast Media