Approach to nutritional rickets

J Pediatr Endocrinol Metab. 2023 Feb 28;36(4):335-341. doi: 10.1515/jpem-2023-0051. Print 2023 Apr 25.

Abstract

Rickets is the disease of a growing skeleton and results from impaired apoptosis of hypertrophic chondrocytes and mineralization of the growth plate. Nutritionally induced rickets, secondary to vitamin D and/or calcium deficiency, remains a major global problem. In this review, we discuss pathogenesis, clinical signs, investigation and management of nutritional rickets.

Keywords: nutritional rickets; rickets; vitamin D; vitamin D deficiency.

Publication types

  • Review

MeSH terms

  • Calcium
  • Humans
  • Malnutrition*
  • Rickets* / diagnosis
  • Rickets* / etiology
  • Rickets* / therapy
  • Vitamin D / therapeutic use
  • Vitamin D Deficiency* / complications
  • Vitamins

Substances

  • Vitamin D
  • Vitamins
  • Calcium