NLRP3 inflammasome activation in response to metals

Front Immunol. 2023 Feb 10;14:1055788. doi: 10.3389/fimmu.2023.1055788. eCollection 2023.


Implant surgery is followed by a series of inflammatory reactions that directly affect its postoperative results. The inflammasome plays a vital role in the inflammatory response by inducing pyroptosis and producing interleukin-1β, which plays a critical role in inflammation and tissue damage. Therefore, it is essential to study the activation of the inflammasome in the bone healing process after implant surgery. As metals are the primary implant materials, metal-induced local inflammatory reactions have received significant attention, and there has been more and more research on the activation of the NLRP3 (NOD-like receptor protein-3) inflammasome caused by these metals. In this review, we consolidate the basic knowledge on the NLRP3 inflammasome structures, the present knowledge on the mechanisms of NLRP3 inflammasome activation, and the studies of metal-induced NLRP3 inflammasome activation.

Keywords: implant; inflammasome; inflammation; metal; osteoimmunology.

Publication types

  • Review

MeSH terms

  • Inflammasomes*
  • NLR Family, Pyrin Domain-Containing 3 Protein*
  • NLR Proteins


  • Inflammasomes
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NLR Proteins

Grant support

This work is supported by the Natural Science Foundation Project of Liaoning Province (2019-ZD-0775 and 2020-MS-150).