Research progress on the protective mechanism of a novel soluble epoxide hydrolase inhibitor TPPU on ischemic stroke

Pan Huang

doi:10.3389/fneur.2023.1083972

Research progress on the protective mechanism of a novel soluble epoxide hydrolase inhibitor TPPU on ischemic stroke

Front Neurol. 2023 Feb 8:14:1083972. doi: 10.3389/fneur.2023.1083972. eCollection 2023.

Author

Pan Huang¹

Affiliation

¹ Department of Neurology, People's Hospital of Deyang City, Deyang, Sichuan, China.

Abstract

Arachidonic Acid (AA) is the precursor of cerebrovascular active substances in the human body, and its metabolites are closely associated with the pathogenesis of cerebrovascular diseases. In recent years, the cytochrome P450 (CYP) metabolic pathway of AA has become a research hotspot. Furthermore, the CYP metabolic pathway of AA is regulated by soluble epoxide hydrolase (sEH). 1-trifluoromethoxyphenyl-3(1-propionylpiperidin-4-yl) urea (TPPU) is a novel sEH inhibitor that exerts cerebrovascular protective activity. This article reviews the mechanism of TPPU's protective effect on ischemic stroke disease.

Keywords: TPPU; arachidonic acid; blood-brain barrier; ischemia reperfusion; ischemic stroke.

Publication types

Review