Craniofacial Fibrous Dysplasia: Clinical and Therapeutic Implications

Curr Osteoporos Rep. 2023 Apr;21(2):147-153. doi: 10.1007/s11914-023-00779-6. Epub 2023 Feb 28.


Purpose of review: This study aims to review diagnosis, potential complications, and clinical management in craniofacial fibrous dysplasia.

Recent findings: Fibrous dysplasia (FD) is a rare mosaic disorder in which normal bone and marrow are replaced with expansile fibro-osseous lesions. Disease presents along a broad spectrum and may be associated with extraskeletal features as part of McCune-Albright syndrome (MAS). The craniofacial skeleton is one of the most commonly impacted areas in FD, and its functional and anatomical complexities create unique challenges for diagnosis and management. This review summarizes current approaches to diagnosis and management in FD/MAS, with emphasis on the clinical and therapeutic implications for the craniofacial skeleton.

Keywords: Craniofacial fibrous dysplasia; Fibrous dysplasia; McCune Albright syndrome; Rare bone disease.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Intramural

MeSH terms

  • Bone and Bones / pathology
  • Craniofacial Fibrous Dysplasia* / complications
  • Fibrous Dysplasia of Bone* / complications
  • Fibrous Dysplasia of Bone* / diagnostic imaging
  • Fibrous Dysplasia of Bone* / therapy
  • Fibrous Dysplasia, Polyostotic* / complications
  • Fibrous Dysplasia, Polyostotic* / diagnosis
  • Fibrous Dysplasia, Polyostotic* / therapy
  • Humans