Review: Research progress of adipose-derived stem cells in the treatment of chronic wounds

Zhuolun Hao; Wenli Qi; Jiaming Sun; Muran Zhou; Nengqiang Guo

doi:10.3389/fchem.2023.1094693

Review: Research progress of adipose-derived stem cells in the treatment of chronic wounds

Front Chem. 2023 Feb 13:11:1094693. doi: 10.3389/fchem.2023.1094693. eCollection 2023.

Authors

Zhuolun Hao¹, Wenli Qi¹, Jiaming Sun¹, Muran Zhou¹, Nengqiang Guo¹

Affiliation

¹ Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Abstract

Although methods are used to treat wounds clinically, there are still many challenges in the treatment of chronic wounds due to excessive inflammatory response, difficulties in epithelialization, vascularization, and other factors. With the increasing research on adipose-derived stem cells (ADSCs) in recent years, accumulating evidence has shown that ADSCs scan promotes the healing of chronic wounds by regulating macrophage function and cellular immunity and promoting angiogenesis and epithelialization. The present study reviewed the difficulties in the treatment of chronic wounds, as well as the advantages and the mechanism of ADSCs in promoting the healing of chronic wounds, to provide a reference for the stem cell therapy of chronic wounds.

Keywords: adipose-derived stem cells; chronic wounds; healing; immunoregulationd; mechanism.

Publication types

Review

Grants and funding

This work was supported by the National Natural Science Foundation of China (No. 82102351) and the Hubei Province Knowledge Innovation Project (2019CFB561).