Folate-Mediated Paclitaxel Nanodelivery Systems: A Comprehensive Review

Turk J Pharm Sci. 2023 Mar 2;20(1):58-67. doi: 10.4274/tjps.galenos.2021.26529.


Paclitaxel (PTX) is used as a viable cancer medication in the chemotherapy of breast, ovarian, lung, bladder, neck, head, and esophageal tumors. The focus of this review is to survey various folate-targeting PTX-loaded nanopreparations in both research and clinical applications. There are diverse nanopreparations, including liposomes, micelles, polymeric nanopreparations, lipid nanopreparations, lipoprotein nanocarriers, and other inorganic nanopreparations for folate-associated PTX tumor targeting. Here, the folate targeting PTX-loaded nanopreparations, which have promising results in the constructive treatment of cancer by reducing toxic side-effects and/or improving effectiveness, was mainly reviewed.

Keywords: Paclitaxel; anticancer; folate receptor; nanopreparations; tumor targeting.