Diagnostic usefulness of SpyGlass in intracholecystic papillary neoplasm with pancreaticobiliary maljunction: a case report and comparison with conventional gallbladder cancer with pancreaticobiliary maljunction

Clin J Gastroenterol. 2023 Jun;16(3):476-481. doi: 10.1007/s12328-023-01778-x. Epub 2023 Mar 3.


Background: Intracholecystic papillary neoplasm (ICPN) is one of the precursors of gallbladder cancer defined in the 2010 World Health Organization classification of tumors. We herein report ICPN with pancreaticobiliary maljunction (PBM), which is a high-risk factor for biliary cancer.

Case presentation: A 57-year-old female presented with abdominal pain. Computed tomography showed a swollen appendix and gallbladder nodules with bile duct dilatation. Endoscopic ultrasonography revealed a gallbladder tumor spreading into the cystic duct confluence accompanying PBM. Based on papillary tumors around the cystic duct detected using the SpyGlass DS II Direct Visualization System (SpyGlass DS), ICPN was suspected. We performed extended cholecystectomy, extrahepatic bile duct resection, and appendectomy with a diagnosis of ICPN and PBM. The pathological diagnosis was ICPN (90 × 50 mm) with high-grade dysplasia spreading into the common bile duct. The absence of residual cancer in the resected specimen was pathologically confirmed. P53 staining was totally negative in both the tumor and normal epithelium. The overexpression of CTNNB1 was not observed.

Conclusions: We encountered a patient with a very rare gallbladder tumor, ICPN with PBM. SpyGlass DS contributed to a precise assessment of the extent of the tumor as well as a qualitative diagnosis.

Keywords: ICPN; Intracholecystic papillary neoplasm; Pancreaticobiliary maljunction.

Publication types

  • Case Reports

MeSH terms

  • Bile Ducts, Extrahepatic* / pathology
  • Carcinoma in Situ* / pathology
  • Common Bile Duct / diagnostic imaging
  • Common Bile Duct / pathology
  • Cystic Duct / pathology
  • Female
  • Gallbladder Neoplasms* / diagnosis
  • Gallbladder Neoplasms* / diagnostic imaging
  • Humans
  • Middle Aged
  • Pancreatic Ducts / diagnostic imaging
  • Pancreatic Ducts / pathology
  • Pancreaticobiliary Maljunction*