Inflammation-the role of TRPA1 channel

Front Physiol. 2023 Feb 16;14:1093925. doi: 10.3389/fphys.2023.1093925. eCollection 2023.


Recently, increasing numbers of studies have demonstrated that transient receptor potential ankyrin 1 (TRPA1) can be used as a potential target for the treatment of inflammatory diseases. TRPA1 is expressed in both neuronal and non-neuronal cells and is involved in diverse physiological activities, such as stabilizing of cell membrane potential, maintaining cellular humoral balance, and regulating intercellular signal transduction. TRPA1 is a multi-modal cell membrane receptor that can sense different stimuli, and generate action potential signals after activation via osmotic pressure, temperature, and inflammatory factors. In this study, we introduced the latest research progress on TRPA1 in inflammatory diseases from three different aspects. First, the inflammatory factors released after inflammation interacts with TRPA1 to promote inflammatory response; second, TRPA1 regulates the function of immune cells such as macrophages and T cells, In addition, it has anti-inflammatory and antioxidant effects in some inflammatory diseases. Third, we have summarized the application of antagonists and agonists targeting TRPA1 in the treatment of some inflammatory diseases.

Keywords: TRPA1; agonist; antagonist; immune cells; inflammatory diseases; inflammatory factors; ion channels.

Publication types

  • Review

Grant support

This study was supported in part by the National Natural Science Foundation of China (82030125, 81873369, and 81973939).