Nucleophosmin Plays a Role in Repairing DNA Damage and Is a Target for Cancer Treatment

Cancer Res. 2023 May 15;83(10):1573-1580. doi: 10.1158/0008-5472.CAN-22-3631.


Nucleophosmin (NPM1) is frequently mutated in acute myeloid leukemia, and NPM1 expression is elevated in several cancer types. NPM1 is a multifunctional oligomeric protein involved in numerous cellular functions that include participating in liquid-liquid phase separation, ribosome biogenesis, chaperoning of histones, and modulation of transcription. In this review, we discuss the underappreciated role of NPM1 in DNA damage repair, specifically Polη-mediated translesion synthesis, base excision, and homologous recombination and highlight the therapeutic potential of NPM1 targeting in cancer treatment.

Publication types

  • Review

MeSH terms

  • DNA Damage
  • DNA Repair
  • Humans
  • Leukemia, Myeloid, Acute* / drug therapy
  • Leukemia, Myeloid, Acute* / therapy
  • Mutation
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism
  • Nucleophosmin*


  • Nucleophosmin
  • Nuclear Proteins