Effects of standardized ginseng extract on learning, memory and physical capabilities

Am J Chin Med. 1987;15(1-2):19-29. doi: 10.1142/S0192415X87000047.


Standardized ginseng extract (G115, Pharmaton, Lugano) was administered orally at doses of 3, 10, 30, 100 and 300 mg/kg for 10 days as ten rats were used with each dose. With the "shuttle-box" method for active avoidance most pronounced effect on learning and memory was obtained by the dose of 10 mg/kg. With the "step-down" method for passive avoidance the dose of 30 mg/kg significantly improved retention. In the staircase maze training with positive (alimentary) reinforcement only the dose of 10 mg/kg significantly improved learning and memory. The dose of 100 mg/kg greatly increased the locomotor activity of mice. The results show that ginseng at appropriate doses improves learning, memory and physical capabilities. Bell-shaped dose-effect curves, reported with other nootropic drugs, were obtained.

MeSH terms

  • Animals
  • Conditioning, Psychological / drug effects
  • Dose-Response Relationship, Drug
  • Drugs, Chinese Herbal / administration & dosage
  • Drugs, Chinese Herbal / pharmacology*
  • Learning / drug effects*
  • Male
  • Memory / drug effects*
  • Motor Activity / drug effects*
  • Panax*
  • Plants, Medicinal*
  • Rats
  • Rats, Inbred Strains


  • Drugs, Chinese Herbal