Pearls & Oy-sters: Case of Atypical Peripheral Nerve Findings Following Paclitaxel for Breast Cancer

Neurology. 2023 Jul 25;101(4):e451-e454. doi: 10.1212/WNL.0000000000207175. Epub 2023 Mar 6.


Neuromuscular ultrasound (NMUS) is a valuable tool in establishing a diagnosis of carpal tunnel syndrome (CTS) and can be particularly helpful in patients with clinical CTS but normal nerve conduction studies (NCSs). This case involves the uncommon presentation of enlarged median nerves on NMUS with normal NCS in a patient with breast cancer who developed chemotherapy-induced peripheral neuropathy and CTS after taxane treatment. This case demonstrates that CTS should not be excluded based on electrodiagnostic studies alone, and comorbid CTS should be considered in patients receiving neurotoxic chemotherapy, even in the setting of normal NCS.

Publication types

  • Case Reports

MeSH terms

  • Breast Neoplasms*
  • Carpal Tunnel Syndrome*
  • Female
  • Humans
  • Median Nerve
  • Neural Conduction / physiology
  • Paclitaxel


  • Paclitaxel