We investigated single nucleotide polymorphisms (SNPs) possibly involved in immune reconstitution inflammatory syndrome of chronic disseminated candidiasis (IRIS-CDC) through a candidate gene approach and a prospective matched-control study. We found that an SNP located in interleukin-1B at rs1143627 was significantly associated with the risk of developing IRIS-CDC.
Keywords: Candida spp; IL-1B; cytokines; genetic polymorphism; immune inflammatory reconstitution syndrome; invasive fungal diseases.
© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.