Syphilitic episcleritis and scleritis

Am J Ophthalmol. 1987 Dec 15;104(6):595-7. doi: 10.1016/0002-9394(87)90170-x.


We screened patients with episcleritis or scleritis to detect syphilis by using either fluorescent treponemal antibody absorption testing or microhemagglutination assay for antibodies to Treponema pallidum. Four patients, two with nodular episcleritis and two with scleritis, had ocular involvement as the initial manifestation of late syphilis. Topical or oral corticosteroid therapy provided minimal initial clinical benefit, but ocular inflammation resolved within one to three weeks after administration of systemic penicillin.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Adult
  • Connective Tissue Diseases / drug therapy
  • Connective Tissue Diseases / etiology*
  • Female
  • Humans
  • Inflammation / drug therapy
  • Inflammation / etiology
  • Inflammation / pathology
  • Middle Aged
  • Penicillin G Benzathine / therapeutic use
  • Sclera* / pathology
  • Syphilis Serodiagnosis
  • Syphilis* / diagnosis
  • Syphilis* / drug therapy


  • Adrenal Cortex Hormones
  • Penicillin G Benzathine