Ankyloblepharon associated with systemic 5-fluorouracil treatment

Ann Ophthalmol. 1987 Oct;19(10):374-5.


A 59-year-old man undergoing systemic 5-fluorouracil treatment for metastatic adenocarcinoma of the stomach developed ocular lesions consisting of bilateral conjunctival ulcers and ulcerative blepharitis leading to ankyloblepharon. Ophthalmologists should be cognizant of potential ocular side effects of chemotherapy, in order to institute appropriate changes in treatment.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / drug therapy
  • Blepharitis / chemically induced
  • Blepharitis / complications
  • Eyelid Diseases / chemically induced*
  • Fluorouracil / adverse effects*
  • Humans
  • Male
  • Middle Aged
  • Skin Ulcer / chemically induced
  • Skin Ulcer / complications
  • Stomach Neoplasms / drug therapy


  • Fluorouracil