The next step in Mendelian randomization

Matthias Weith; Andreas Beyer

doi:10.7554/eLife.86416

The next step in Mendelian randomization

Elife. 2023 Mar 9:12:e86416. doi: 10.7554/eLife.86416.

Authors

Matthias Weith¹, Andreas Beyer²

Affiliations

¹ Cologne Excellence Cluster on Cellular Stress Responses in Age-Associated Diseases, and the Institute for Biochemistry, University of Cologne, Cologne, Germany.
² Cologne Excellence Cluster on Cellular Stress Responses in Age-Associated Diseases, the Faculty of Medicine and University Hospital of Cologne, the Center for Molecular Medicine Cologne, and the Institute for Genetics, University of Cologne, Cologne, Germany.

Abstract

Expanding a statistical approach called Mendelian randomization to include multiple variables may help researchers to identify new molecular causes of specific traits.

Keywords: causal inference; gene expression; genetics; genomics; human; metabolomics; multiomics.

Publication types

Editorial
Comment

MeSH terms

Causality
Genome-Wide Association Study*
Mendelian Randomization Analysis*
Phenotype