The SARS-CoV-2 main protease induces neurotoxic TDP-43 cleavage and aggregates

Affiliations

• ¹ Institute of Virology and AIDS Research, First Hospital, Jilin University, Changchun, Jilin, 130021, China.
• ² Department of Neurology and Neuroscience Center, First Hospital, Jilin University, Changchun, Jilin, 130021, China.
• ³ Key Laboratory for Experimental Teratology of Ministry of Education and Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, China.
• ⁴ Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
• ⁵ Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China.
• ⁶ Institute of Virology and AIDS Research, First Hospital, Jilin University, Changchun, Jilin, 130021, China. wwei6@jlu.edu.cn.
• ⁷ Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Translational Medicine, First Hospital, Jilin University, Changchun, Jilin, 130021, China. wwei6@jlu.edu.cn.