A rigid-axle-based molecular rotaxane channel facilitates K+/Cl- co-transport across a lipid membrane

Chem Commun (Camb). 2023 Mar 28;59(26):3866-3869. doi: 10.1039/d3cc00811h.

Abstract

Inspired by the design criteria of heteroditopic receptors for ion-pair binding, we herein describe a new strategy to construct a rotaxane transporter (RR[2]) for K+/Cl- co-transport. The use of a rigid axle improves the transport activity with an EC50 value of 0.58 μM, presenting a significant step toward developing rotaxane artificial channels.

MeSH terms

  • Lipids
  • Membrane Transport Proteins
  • Rotaxanes* / chemistry

Substances

  • Rotaxanes
  • Membrane Transport Proteins
  • Lipids