Painless progressive mononeuritis multiplex secondary to AML associated neuroleukemiosis

J Neuroimmunol. 2023 Apr 15:377:578061. doi: 10.1016/j.jneuroim.2023.578061. Epub 2023 Mar 5.


Neuroleukemiosis describes peripheral nerve involvement secondary to leukemic infiltration, a rare complication of leukemia with various clinical presentations, leading to diagnostic challenges for hematologists and neurologists. We present two cases of painless progressive mononeuritis multiplex secondary to neuroleukemiosis. A literature review of previously reported cases of neuroleukemiosis was undertaken. Neuroleukemiosis may present as a progressive mononeuritis multiplex. The diagnosis of neuroleukemiosis requires a high index of suspicion and be aided by repeated CSF analysis.

Keywords: Leukemia; Mononeuritis multiplex; Neuroleukemiosis; Neuropathy.

Publication types

  • Review

MeSH terms

  • Humans
  • Leukemia, Myeloid, Acute* / complications
  • Leukemic Infiltration / complications
  • Mononeuropathies* / complications
  • Mononeuropathies* / diagnosis
  • Peripheral Nerves