Macrophage Biology in Human Granulomatous Skin Inflammation

Int J Mol Sci. 2023 Feb 27;24(5):4624. doi: 10.3390/ijms24054624.


Cutaneous granulomatoses represent a heterogeneous group of diseases, which are defined by macrophage infiltration in the skin. Skin granuloma can be formed in the context of infectious and non-infectious conditions. Recent technological advances have deepened our understanding of the pathophysiology of granulomatous skin inflammation, and they provide novel insights into human tissue macrophage biology at the site of ongoing disease. Here, we discuss findings on macrophage immune function and metabolism derived from three prototypic cutaneous granulomatoses: granuloma annulare, sarcoidosis, and leprosy.

Keywords: granuloma; granuloma annulare; immune function; interferon-γ; leprosy; macrophage; metabolism; sarcoidosis.

Publication types

  • Review

MeSH terms

  • Biology
  • Dermatitis*
  • Humans
  • Inflammation
  • Macrophages
  • Sarcoidosis*
  • Skin
  • Skin Diseases*