Highly Sensitive and Selective Dopamine Determination in Real Samples Using Au Nanoparticles Decorated Marimo-like Graphene Microbead-Based Electrochemical Sensors

Qichen Tian; Yuanbin She; Yangguang Zhu; Dan Dai; Mingjiao Shi; Wubo Chu; Tao Cai; Hsu-Sheng Tsai; He Li; Nan Jiang; Li Fu; Hongyan Xia; Cheng-Te Lin; Chen Ye

doi:10.3390/s23052870

Highly Sensitive and Selective Dopamine Determination in Real Samples Using Au Nanoparticles Decorated Marimo-like Graphene Microbead-Based Electrochemical Sensors

Sensors (Basel). 2023 Mar 6;23(5):2870. doi: 10.3390/s23052870.

Authors

Qichen Tian^{1

2}, Yuanbin She¹, Yangguang Zhu², Dan Dai^{1

2}, Mingjiao Shi², Wubo Chu^{2

3

4}, Tao Cai^{2

3

4}, Hsu-Sheng Tsai^{5

6}, He Li^{2

3

4}, Nan Jiang^{2

3

4}, Li Fu⁷, Hongyan Xia⁸, Cheng-Te Lin^{2

3

4}, Chen Ye^{2

3

4}

Affiliations

¹ College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
² Qianwan Institute, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences, Ningbo 315201, China.
³ Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China.
⁴ Key Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences, Ningbo 315201, China.
⁵ Laboratory for Space Environment and Physical Sciences, Harbin Institute of Technology, Harbin 150001, China.
⁶ School of Physics, Harbin Institute of Technology, Harbin 150001, China.
⁷ College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, China.
⁸ State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China.

Abstract

A sensitive and selective electrochemical dopamine (DA) sensor has been developed using gold nanoparticles decorated marimo-like graphene (Au NP/MG) as a modifier of the glassy carbon electrode (GCE). Marimo-like graphene (MG) was prepared by partial exfoliation on the mesocarbon microbeads (MCMB) through molten KOH intercalation. Characterization via transmission electron microscopy confirmed that the surface of MG is composed of multi-layer graphene nanowalls. The graphene nanowalls structure of MG provided abundant surface area and electroactive sites. Electrochemical properties of Au NP/MG/GCE electrode were investigated by cyclic voltammetry and differential pulse voltammetry techniques. The electrode exhibited high electrochemical activity towards DA oxidation. The oxidation peak current increased linearly in proportion to the DA concentration in a range from 0.02 to 10 μM with a detection limit of 0.016 μM. The detection selectivity was carried out with the presence of 20 μM uric acid in goat serum real samples. This study demonstrated a promising method to fabricate DA sensor-based on MCMB derivatives as electrochemical modifiers.

Keywords: dopamine determination; electrochemical sensors; gold nanoparticles; graphene nanowalls; mesocarbon microbeads.

Abstract

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