Synthesis of heparin fragments: a methyl alpha-pentaoside with high affinity for antithrombin III

M Petitou; P Duchaussoy; I Lederman; J Choay; J C Jacquinet; P Sinaÿ; G Torri

doi:10.1016/0008-6215(87)80268-9

Synthesis of heparin fragments: a methyl alpha-pentaoside with high affinity for antithrombin III

Carbohydr Res. 1987 Sep 15:167:67-75. doi: 10.1016/0008-6215(87)80268-9.

Authors

M Petitou¹, P Duchaussoy, I Lederman, J Choay, J C Jacquinet, P Sinaÿ, G Torri

Affiliation

¹ Institut Choay, Paris, France.

PMID: 3690577
DOI: 10.1016/0008-6215(87)80268-9

Abstract

The synthesis is described of the methyl alpha-glycoside of the pentasaccharide which represents the sequence in heparin responsible for binding and activation of the anticoagulant protein Antithrombin III. It was obtained in a yield much better than that of the previously synthesised pentasaccharide and exhibited the same biological properties.

MeSH terms

Antithrombin III / metabolism*
Heparin / chemical synthesis*
Heparin / metabolism
Indicators and Reagents
Magnetic Resonance Spectroscopy
Oligosaccharides / chemical synthesis*
Oligosaccharides / metabolism
Optical Rotation
Structure-Activity Relationship

Substances

Indicators and Reagents
Oligosaccharides
Antithrombin III
Heparin