Role of ferroptosis in colorectal cancer

Ya-Qi Song; Xiao-Dan Yan; Yi Wang; Zhen-Zhen Wang; Xin-Li Mao; Li-Ping Ye; Shao-Wei Li

doi:10.4251/wjgo.v15.i2.225

Role of ferroptosis in colorectal cancer

World J Gastrointest Oncol. 2023 Feb 15;15(2):225-239. doi: 10.4251/wjgo.v15.i2.225.

Authors

Ya-Qi Song¹, Xiao-Dan Yan², Yi Wang², Zhen-Zhen Wang², Xin-Li Mao², Li-Ping Ye^{1

2

3}, Shao-Wei Li^{2

3

4}

Affiliations

¹ Taizhou Hospital of Zhejiang Province, Zhejiang University, Linhai 317000, Zhejiang Province, China.
² Department of Gastroenterology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai 317000, Zhejiang Province, China.
³ Institute of Digestive Disease, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai 317000, Zhejiang Province, China.
⁴ Key Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai 317000, Zhejiang Province, China. li_shaowei81@hotmail.com.

Abstract

Colorectal cancer (CRC) is the second deadliest cancer and the third-most common malignancy in the world. Surgery, chemotherapy, and targeted therapy have been widely used to treat CRC, but some patients still develop resistance to these treatments. Ferroptosis is a novel non-apoptotic form of cell death. It is an iron-dependent non-apoptotic cell death characterized by the accumulation of lipid reactive oxygen species and has been suggested to play a role in reversing resistance to anticancer drugs. This review summarizes recent advances in the prognostic role of ferroptosis in CRC and the mechanism of action in CRC.

Keywords: Colorectal cancer; Ferroptosis; Glutathione; Glutathione peroxidase 4; System Xc−.

Publication types

Review