Case report: Uncommon multiple metastases from occult breast cancer revealed by 68Ga-DOTATATE PET/CT

Tianyuan Hu; Rongqin Zhang; Bing Zhang; Shanzhen He; Lian Liu; Yan Zou; Junhao Huang; Bing Wang; Ping Hu; Zhanwen Zhang

doi:10.3389/fonc.2023.1106890

Case report: Uncommon multiple metastases from occult breast cancer revealed by ⁶⁸Ga-DOTATATE PET/CT

Front Oncol. 2023 Feb 22:13:1106890. doi: 10.3389/fonc.2023.1106890. eCollection 2023.

Authors

Tianyuan Hu¹, Rongqin Zhang^{1

2}, Bing Zhang³, Shanzhen He⁴, Lian Liu¹, Yan Zou¹, Junhao Huang¹, Bing Wang¹, Ping Hu¹, Zhanwen Zhang¹

Affiliations

¹ Department of Nuclear Medicine, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
² Department of Nuclear Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China.
³ Department of Nuclear Medicine and Medical Imaging, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
⁴ Department of Nuclear Medicine, Guangdong Provincial People's Hospital, Guangzhou, Guangdong, China.

Abstract

Occult breast cancer is an uncommon type of breast cancer and its diagnosis is challenging. It is usually invisible on multiple imaging examines. Metastases to the rectum and inguinal lymph nodes from occult breast lobular cancer are even rarer. ⁶⁸Ga-DOTA peptides can image neuroendocrine tumors by targeting specific somatostatin receptors. Besides, other tumors, including breast cancer, have been shown to express somatostatin receptors. In this case, we presented a 63-year-old woman who underwent both ¹⁸F-FDG and ⁶⁸Ga-DOTATATE PET/CT due to a rectal polyp. An endoscopic excision biopsy confirmed metastatic carcinoma of suspected breast origin, but subsequent ultrasound and MRI showed no signs of malignancy in the breast and adnexa uteri. PET/CT showed obvious ⁶⁸Ga-DOTATATE activity in bilateral axillary and right inguinal lymph nodes with mild ¹⁸F-FDG uptake. Final histopathology at the left axillary, right inguinal lymph nodes, and rectum indicated metastases from breast cancer while the origin remained radiologically occult. Additionally, one uterine fibroids was found with positive uptake of ⁶⁸Ga-DOTATATE and negative uptake of ¹⁸F-FDG. This case suggested that ⁶⁸Ga-DOTATAE PET/CT may be an effective supplement in diagnosing OBC lymph node metastases with mild ¹⁸F-FDG uptake, and it may provide a new technology for the clinical diagnosis of occult breast cancer.

Keywords: 18F-FDG; 68Ga-DOTATATE; PET/CT; lymph node metastases; occult breast cancer.

Publication types

Case Reports

Grants and funding

This research supported in part by the National Natural Science Foundation of China (No.81901772), the Natural Science Foundation of Guangdong Province, China (No. 2019A1515011893), the State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia & The First People’s Hospital of Kashi Fund (No.SKL-HIDCA-2020-KS2), Guangzhou Basic and Applied Basic Research Foundation (No.202102080400).