Tumor characteristics in colorectal cancer and their relationship to treatment and prognosis

Dis Colon Rectum. 1987 Dec;30(12):934-8. doi: 10.1007/BF02554279.


Two hundred sixty one patients with adenocarcinoma of the colon and rectum were studied with respect to histopathologic and macroscopic tumor characteristics. Nonmetastatic disease was associated significantly with well-differentiated tumors, tumors with pronounced inflammation, and polypoid adenocarcinomas. There was a higher proportion of poorly-differentiated tumors in the right colon. Inflammatory changes were uncommon in rectal lesions; these tumors were more often polypoid than in other locations. Survival was significantly influenced by tumor differentiation, degree of inflammation, macroscopic appearance, and tumor size. Well-differentiated adenocarcinomas, less than 2 cm in diameter, and well-differentiated polypoid adenocarcinomas, less than 4 cm in diameter, were all found in patients with Dukes' stage A tumors. Such patients may be candidates for local excision if the tumor is located in the distal part of the rectum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / mortality
  • Adenocarcinoma / pathology*
  • Adenocarcinoma / surgery
  • Adult
  • Aged
  • Aged, 80 and over
  • Colonic Neoplasms / mortality
  • Colonic Neoplasms / pathology*
  • Colonic Neoplasms / surgery
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Prognosis
  • Rectal Neoplasms / mortality
  • Rectal Neoplasms / pathology*
  • Rectal Neoplasms / surgery