Contact allergy to a contaminant in Kathon CG in the guinea pig

Derm Beruf Umwelt. 1987 Sep-Oct;35(5):165-8.

Abstract

Kathon CG is a commercial preservative, consisting of the two active ingredients, 2-methyl-4-isothiazolin-3-one and 5-chloro-2-methyl-4-isothiazolin-3-one (5243-K-CG) and other components. 4,5-dichloro-2-methyl-4-isothiazolin-3-one (45243-K-CG) is a contaminant in Kathon CG. The chemically related active ingredients are known to be contact sensitizers in humans and guinea pigs. Aims of this study were to determine the sensitizing capacity of this contaminant and also to investigate the cross-reaction pattern by guinea pig sensitization tests. 45243-K-CG was demonstrated to be a strong sensitizer; all animals reacting to 45243-K-CG also reacted to 5243-K-CG when rechallenged.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromatography, High Pressure Liquid
  • Dermatitis, Contact / etiology*
  • Drug Contamination
  • Female
  • Guinea Pigs
  • Intradermal Tests
  • Pharmaceutic Aids*
  • Preservatives, Pharmaceutical*
  • Structure-Activity Relationship
  • Thiazoles / analysis
  • Thiazoles / toxicity*

Substances

  • Pharmaceutic Aids
  • Preservatives, Pharmaceutical
  • Thiazoles
  • Kathon 886