Associations between self-reported sleep quality and cerebrospinal fluid biomarkers in mild cognitive impairment and Alzheimer's disease

J Durães; P Marques; A M Novo; J Facas; D Duro; M Lima; M J Leitão; M Tábuas-Pereira; I Baldeiras; I Santana

doi:10.1016/j.neurol.2022.12.009

Associations between self-reported sleep quality and cerebrospinal fluid biomarkers in mild cognitive impairment and Alzheimer's disease

Rev Neurol (Paris). 2023 Oct;179(8):877-881. doi: 10.1016/j.neurol.2022.12.009. Epub 2023 Mar 11.

Authors

J Durães¹, P Marques², A M Novo², J Facas³, D Duro⁴, M Lima⁵, M J Leitão⁴, M Tábuas-Pereira⁶, I Baldeiras⁶, I Santana⁶

Affiliations

¹ Department of Neurology, Centro Hospitalar e Universitário de Coimbra, 3000-045 Coimbra, Portugal; Faculty of Medicine, University of Coimbra, 3000-370 Coimbra, Portugal; Center for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-517 Coimbra, Portugal. Electronic address: 11038@chuc.min-saude.pt.
² Department of Neurology, Centro Hospitalar e Universitário de Coimbra, 3000-045 Coimbra, Portugal.
³ Department of Medical Imaging, Centro Hospitalar e Universitário de Coimbra, 3000-045 Coimbra, Portugal.
⁴ Department of Neurology, Centro Hospitalar e Universitário de Coimbra, 3000-045 Coimbra, Portugal; Center for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-517 Coimbra, Portugal.
⁵ Department of Neurology, Centro Hospitalar e Universitário de Coimbra, 3000-045 Coimbra, Portugal; Faculty of Psychology and Educational Sciences, University of Coimbra, Center for Research in Neuropsychology and Cognitive Behavioral Intervention (CINEICC), 3000-115 Coimbra, Portugal; Center for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-517 Coimbra, Portugal.
⁶ Department of Neurology, Centro Hospitalar e Universitário de Coimbra, 3000-045 Coimbra, Portugal; Faculty of Medicine, University of Coimbra, 3000-370 Coimbra, Portugal; Center for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-517 Coimbra, Portugal.

PMID: 36914478
DOI: 10.1016/j.neurol.2022.12.009

Abstract

Sleep disorders are very common in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Several parameters of polysomnography seem to correlate with cognitive scores and amyloid biomarkers in the different stages of AD. However, there is limited evidence for the relationship between self-reported sleep impairment and disease biomarkers. In this study, we assessed the relationship between self-reported sleep complaints, with the Pittsburgh Sleep Quality Index, and both cognitive function and cerebrospinal fluid biomarkers in 70 patients with MCI and 78 patients with AD. Sleep duration and daytime dysfunction were higher in AD. Daytime dysfunction had a negative correlation with cognitive scores (Mini-Mental-State Examination and Montreal Cognitive Assessment) and with amyloid-beta_1-42 protein, and a positive correlation with total tau protein. However, daytime dysfunction was an independent predictor only of t-tau values (F=57.162; 95% CI: [18.118; 96.207], P=0.004). These findings support a relationship between daytime dysfunction, cognitive scores and neurodegeneration, further expanding recent findings that it may signal a risk of dementia.

Keywords: Biomarker; Dementia; Neurodegeneration; Sleep; Tau.

MeSH terms

Alzheimer Disease* / diagnosis
Alzheimer Disease* / epidemiology
Amyloid beta-Peptides / cerebrospinal fluid
Biomarkers
Cognitive Dysfunction* / diagnosis
Cognitive Dysfunction* / epidemiology
Cognitive Dysfunction* / etiology
Humans
Self Report
Sleep Quality
tau Proteins

Substances

tau Proteins
Amyloid beta-Peptides
Biomarkers