Derivatives of 1,2,3,3-tetramethyl-2-azabicyclo[2.2.2]octan-5-trans-ol with antiarrhythmic and other activities. VIII

M Longobardi; A Bargagna; P Schenone; D De Santis; M Angrisani; E Marmo

Derivatives of 1,2,3,3-tetramethyl-2-azabicyclo[2.2.2]octan-5-trans-ol with antiarrhythmic and other activities. VIII

Farmaco Sci. 1987 Sep;42(9):691-6.

Authors

M Longobardi¹, A Bargagna, P Schenone, D De Santis, M Angrisani, E Marmo

Affiliation

¹ Istituto di Scienze Farmaceutiche, Università di Genova, Italy.

PMID: 3691791

Abstract

The synthesis of some alkyl, aryl thioureas and aryl ureas starting from 5-trans-(3-aminopropoxy)-1,2,3,3-tetramethyl-2-azabicyclo[2.2.2]octane is described. Some thioureas showed a remarkable antiarrhythmic activity besides a weak hypotensive effect in rats and, like some ureas, infiltration anesthesia in mice.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anesthetics, Local / chemical synthesis
Animals
Anti-Arrhythmia Agents / chemical synthesis*
Blood Pressure / drug effects
Bridged Bicyclo Compounds / chemical synthesis*
Bridged Bicyclo Compounds / pharmacology
Bridged-Ring Compounds / chemical synthesis*
Chemical Phenomena
Chemistry
Heart Rate / drug effects
Mice
Rats

Substances

Anesthetics, Local
Anti-Arrhythmia Agents
Bridged Bicyclo Compounds
Bridged-Ring Compounds