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. 2023 May 1;159(5):560-563.
doi: 10.1001/jamadermatol.2023.0175.

Assessment of Clinical Response to Anifrolumab in Patients With Refractory Discoid Lupus Erythematosus

Katharina Shaw  1 , Stephanie Sanchez-Melendez  1 , Dustin Taylor  1 , Julia Barker  2 , Avery LaChance  1 , Neda Shahriari  1 , Ruth Ann Vleugels  1
Affiliations

Assessment of Clinical Response to Anifrolumab in Patients With Refractory Discoid Lupus Erythematosus

Katharina Shaw et al. JAMA Dermatol. .
No abstract available

Plain language summary

This case series examines the efficacy of anifrolumab as a therapeutic option for patients with lupus erythematosus.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr LaChance reported grants from Pfizer outside the submitted work. Dr Vleugels reported grants from Pfizer PI outside the submitted work. No other disclosures were reported.

Figures

Figure.
Figure.. Representative Clinical Images Before and After 2 Months of Treatment With Anifrolumab
A woman in her 40s with a history of long-standing DLE on chronic prednisone (10 mg daily) with extensive erythematous, scaly plaques with peripheral hyperpigmentation involving the face, scalp (A), extremities (B), and chest (C). Her disease had previously proven refractory to hydroxychloroquine, mycophenolate mofetil, methotrexate, azathioprine, and rituximab. After 2 months of treatment with anifrolumab, the patient still exhibited extensive postinflammatory hyperpigmentation and scarring, but experienced dramatic improvement in disease activity with reduced erythema and scaling (D-F). After 6 months of treatment with anifrolumab, prednisone was successfully weaned from 10 mg to 2 mg daily.
See this image and copyright information in PMC

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