Hepatotoxicity of mebendazole. Relationship with serum concentrations of the drug

A Bekhti; J Pirotte

Hepatotoxicity of mebendazole. Relationship with serum concentrations of the drug

Gastroenterol Clin Biol. 1987 Oct;11(10):701-3.

Authors

A Bekhti¹, J Pirotte

Affiliation

¹ Secteur de Gastroentérologie, Institut de Médecine, Hôpital de Bavière, Liège, Belgique.

PMID: 3692093

Abstract

We report the case of a 47-year-old female patient, suffering from multiple hydatid cysts of the liver, in whom hepatitis developed after mebendazole treatment. Clinical manifestations of hypersensitivity were absent. A correlation was found between serum mebendazole concentrations and the degree of cytolysis; this is compatible with a direct hepatotoxic effect of mebendazole.

Publication types

Case Reports

MeSH terms

Alanine Transaminase / blood
Chemical and Drug Induced Liver Injury / blood*
Chemical and Drug Induced Liver Injury / enzymology
Chemical and Drug Induced Liver Injury / etiology
Echinococcosis, Hepatic / drug therapy
Female
Humans
Mebendazole / adverse effects*
Mebendazole / blood
Mebendazole / therapeutic use
Middle Aged

Substances

Mebendazole
Alanine Transaminase