Three-component synthesis of N-naphthyl pyrazoles via Rh(III)-catalyzed cascade pyrazole annulation and Satoh-Miura benzannulation

Demao Chen; Liyun Zhou; Yunyun Liu; Jie-Ping Wan

doi:10.1039/d3cc00649b

Three-component synthesis of N-naphthyl pyrazoles via Rh(III)-catalyzed cascade pyrazole annulation and Satoh-Miura benzannulation

Chem Commun (Camb). 2023 Mar 30;59(27):4036-4039. doi: 10.1039/d3cc00649b.

Authors

Demao Chen¹, Liyun Zhou¹, Yunyun Liu¹, Jie-Ping Wan^{1

2}

Affiliations

¹ National Engineering Research Center for Carbohydrate Synthesis, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, China. wanjieping@jxnu.edu.cn.
² International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037, China.

PMID: 36924202
DOI: 10.1039/d3cc00649b

Abstract

The synthesis of N-naphthyl pyrazoles has been realized by the direct three-component reactions of enaminones, aryl hydrazine hydrochlorides and internal alkynes via Rh(III) catalysis. The synthetic reactions employing simple substrates lead to simultaneous construction of dual cyclic moieties, including a pyrazole ring and a phenyl ring, via sequential formation of two C-N and three C-C bonds.