Increased transmigration of intermediate monocytes associated with atherosclerotic burden in people with HIV on antiretroviral therapy

AIDS. 2023 Jun 1;37(7):1177-1179. doi: 10.1097/QAD.0000000000003534. Epub 2023 Mar 3.


This study evaluated the association between the transmigration of monocyte subpopulations that contributes to atherosclerosis development, along with surrogate biomarkers of inflammation and atherosclerosis, through carotid intima-media thickness (cIMT) measurements of 72 people with HIV (PWH) on suppressive antiretroviral therapy (ART). We found that the transmigration of intermediate monocytes was positively correlated with D-dimer and cIMT, suggesting that intermediate monocytes may have a greater propensity to promote cardiovascular disease (CVD) in PWH on ART.

Publication types

  • Research Support, N.I.H., Extramural
  • Letter

MeSH terms

  • Atherosclerosis* / complications
  • Cardiovascular Diseases* / complications
  • Carotid Intima-Media Thickness
  • HIV Infections* / complications
  • HIV Infections* / drug therapy
  • Humans
  • Monocytes
  • Risk Factors