Structural and functional asymmetry of the neonatal cerebral cortex

doi:10.1038/s41562-023-01542-8

Comparative Study

. 2023 Jun;7(6):942-955.

doi: 10.1038/s41562-023-01542-8. Epub 2023 Mar 16.

Structural and functional asymmetry of the neonatal cerebral cortex

Logan Z J Williams^{1

2}, Sean P Fitzgibbon³, Jelena Bozek⁴, Anderson M Winkler⁵, Ralica Dimitrova⁶, Tanya Poppe⁶, Andreas Schuh⁷, Antonios Makropoulos⁶, John Cupitt⁷, Jonathan O'Muircheartaigh^{6

8

9}, Eugene P Duff^{3

10}, Lucilio Cordero-Grande^{6

11}, Anthony N Price^{6

12}, Joseph V Hajnal^{6

12}, Daniel Rueckert^{7

13}, Stephen M Smith³, A David Edwards^{6

9

14}, Emma C Robinson^{15

16}

Affiliations

¹ Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK. logan.williams@kcl.ac.uk.
² Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Science, King's College London, London, UK. logan.williams@kcl.ac.uk.
³ Centre for Functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.
⁴ Faculty of Electrical Engineering and Computing, University of Zagreb, Zagreb, Croatia.
⁵ Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
⁶ Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
⁷ Department of Computing, Imperial College London, London, UK.
⁸ Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
⁹ MRC Centre for Neurodevelopmental Disorders, King's College London, London, UK.
¹⁰ UK Dementia Research Institute, Department of Brain Sciences, Imperial College London, London, UK.
¹¹ Biomedical Image Technologies, ETSI Telecomunicación, Universidad Politécnica de Madrid and CIBER-BBN, ISCIII, Madrid, Spain.
¹² Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Science, King's College London, London, UK.
¹³ Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
¹⁴ Neonatal Intensive Care Unit, Evelina London Children's Hospital, London, UK.
¹⁵ Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK. emma.robinson@kcl.ac.uk.
¹⁶ Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Science, King's College London, London, UK. emma.robinson@kcl.ac.uk.

PMID: 36928781
DOI: 10.1038/s41562-023-01542-8

Comparative Study

Structural and functional asymmetry of the neonatal cerebral cortex

Logan Z J Williams et al. Nat Hum Behav. 2023 Jun.

. 2023 Jun;7(6):942-955.

doi: 10.1038/s41562-023-01542-8. Epub 2023 Mar 16.

Authors

Affiliations

¹ Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK. logan.williams@kcl.ac.uk.
² Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Science, King's College London, London, UK. logan.williams@kcl.ac.uk.
³ Centre for Functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.
⁴ Faculty of Electrical Engineering and Computing, University of Zagreb, Zagreb, Croatia.
⁵ Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
⁶ Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
⁷ Department of Computing, Imperial College London, London, UK.
⁸ Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
⁹ MRC Centre for Neurodevelopmental Disorders, King's College London, London, UK.
¹⁰ UK Dementia Research Institute, Department of Brain Sciences, Imperial College London, London, UK.
¹¹ Biomedical Image Technologies, ETSI Telecomunicación, Universidad Politécnica de Madrid and CIBER-BBN, ISCIII, Madrid, Spain.
¹² Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Science, King's College London, London, UK.
¹³ Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
¹⁴ Neonatal Intensive Care Unit, Evelina London Children's Hospital, London, UK.
¹⁵ Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK. emma.robinson@kcl.ac.uk.
¹⁶ Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Science, King's College London, London, UK. emma.robinson@kcl.ac.uk.

PMID: 36928781
DOI: 10.1038/s41562-023-01542-8

Abstract

Features of brain asymmetry have been implicated in a broad range of cognitive processes; however, their origins are still poorly understood. Here we investigated cortical asymmetries in 442 healthy term-born neonates using structural and functional magnetic resonance images from the Developing Human Connectome Project. Our results demonstrate that the neonatal cortex is markedly asymmetric in both structure and function. Cortical asymmetries observed in the term cohort were contextualized in two ways: by comparing them against cortical asymmetries observed in 103 preterm neonates scanned at term-equivalent age, and by comparing structural asymmetries against those observed in 1,110 healthy young adults from the Human Connectome Project. While associations with preterm birth and biological sex were minimal, significant differences exist between birth and adulthood.

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References

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[1] Mazoyer, B. et al. Gaussian mixture modeling of hemispheric lateralization for language in a large sample of healthy individuals balanced for handedness. PLoS ONE 9, e101165 (2014). - PubMed - PMC

[2] Mazoyer, B. et al. Gaussian mixture modeling of hemispheric lateralization for language in a large sample of healthy individuals balanced for handedness. PLoS ONE 9, e101165 (2014). - PubMed - PMC

[3] Zhen, Z. et al. Quantifying interindividual variability and asymmetry of face-selective regions: a probabilistic functional atlas. NeuroImage 113, 13–25 (2015). - PubMed

[4] Zhen, Z. et al. Quantifying interindividual variability and asymmetry of face-selective regions: a probabilistic functional atlas. NeuroImage 113, 13–25 (2015). - PubMed

[5] Postema, M. C. et al. Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets. Nat. Commun. 10, 1–12 (2019).

[6] Postema, M. C. et al. Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets. Nat. Commun. 10, 1–12 (2019).

[7] Damme, K. S., Vargas, T., Calhoun, V., Turner, J. & Mittal, V. A. Global and specific cortical volume asymmetries in individuals with psychosis risk syndrome and schizophrenia: a mixed cross-sectional and longitudinal perspective. Schizophr. Bull. 46, 713–721 (2020). - PubMed

[8] Damme, K. S., Vargas, T., Calhoun, V., Turner, J. & Mittal, V. A. Global and specific cortical volume asymmetries in individuals with psychosis risk syndrome and schizophrenia: a mixed cross-sectional and longitudinal perspective. Schizophr. Bull. 46, 713–721 (2020). - PubMed

[9] Kong, X.-Z. et al. Mapping cortical and subcortical asymmetry in obsessive-compulsive disorder: findings from the enigma consortium. Biol. Psychiatry 87, 1022–1034 (2020). - PubMed

[10] Kong, X.-Z. et al. Mapping cortical and subcortical asymmetry in obsessive-compulsive disorder: findings from the enigma consortium. Biol. Psychiatry 87, 1022–1034 (2020). - PubMed

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Structural and functional asymmetry of the neonatal cerebral cortex

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Structural and functional asymmetry of the neonatal cerebral cortex

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