The Who, What, When and Where of Inpatient Direct Oral Penicillin Challenge - Implications for health services implementation

Clin Infect Dis. 2023 Mar 17;ciad156. doi: 10.1093/cid/ciad156. Online ahead of print.


Inpatient direct oral challenge programs are increasingly deployed as part of antimicrobial stewardship (AMS) initiatives to reduce the burden and impacts of penicillin allergy labels on antibiotic prescribing. Using data from a prospective multicentre cohort inpatient penicillin allergy program, we identify the key targets for delabeling to aid health service implementation.

Keywords: amoxicillin allergy; antimicrobial stewardship; beta-lactam allergy; drug allergy; oral provocation.