Deciphering breast cancer: from biology to the clinic

Cell. 2023 Apr 13;186(8):1708-1728. doi: 10.1016/j.cell.2023.01.040. Epub 2023 Mar 16.


Breast cancer remains a leading cause of cancer-related mortality in women, reflecting profound disease heterogeneity, metastasis, and therapeutic resistance. Over the last decade, genomic and transcriptomic data have been integrated on an unprecedented scale and revealed distinct cancer subtypes, critical molecular drivers, clonal evolutionary trajectories, and prognostic signatures. Furthermore, multi-dimensional integration of high-resolution single-cell and spatial technologies has highlighted the importance of the entire breast cancer ecosystem and the presence of distinct cellular "neighborhoods." Clinically, a plethora of new targeted therapies has emerged, now being rapidly incorporated into routine care. Resistance to therapy, however, remains a crucial challenge for the field.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms* / pathology
  • Breast Neoplasms* / therapy
  • Drug Resistance, Neoplasm
  • Female
  • Gene Expression Profiling
  • Genomics
  • Humans
  • Transcriptome