Clinical validation of the international study group of pancreatic surgery (ISGPS) definition for post-pancreatectomy acute pancreatitis

HPB (Oxford). 2023 Jun;25(6):704-710. doi: 10.1016/j.hpb.2023.01.014. Epub 2023 Feb 3.


Background: The diagnosis of postoperative or post-pancreatectomy acute pancreatitis (PPAP) is controversial. In 2021, the International Study Group of Pancreatic Surgery (ISGPS) published the first unifying definition and grading system for PPAP. This study sought to validate recent consensus criteria, using a cohort of patients undergoing pancreaticoduodenectomy (PD) in a high-volume pancreaticobiliary specialty unit.

Methods: All consecutive patients undergoing PD at a tertiary referral centre between January 2016 and December 2021 were retrospectively reviewed. Patients with serum amylase recorded within 48h from surgery were included for analysis. Postoperative data were extracted and evaluated against the ISGPS criteria, including the presence of postoperative hyperamylasaemia, radiologic features consistent with acute pancreatitis, and clinical deterioration.

Results: A total of 82 patients were evaluated. The overall incidence of PPAP was 32% (26/82) in this cohort, of which 3/26 demonstrated postoperative hyperamylasaemia and 23/26 had clinically relevant PPAP (Grade B or C) when correlated radiologic and clinical criteria.

Conclusions: This study is among the first to apply the recently published consensus criteria for PPAP diagnosis and grading to clinical data. While the results support their utility in establishing PPAP as a distinct post-pancreatectomy complication, there remains a need for future large-scale validation studies.

MeSH terms

  • Acute Disease
  • Humans
  • Pancreatectomy* / adverse effects
  • Pancreatectomy* / methods
  • Pancreatic Fistula / etiology
  • Pancreaticoduodenectomy / adverse effects
  • Pancreaticoduodenectomy / methods
  • Pancreatitis* / complications
  • Pancreatitis* / etiology
  • Postoperative Complications / diagnosis
  • Postoperative Complications / etiology
  • Retrospective Studies


  • N-(3-phenyl-n-propyl)-1-phenyl-2-aminopropane