Chorea: An unusual manifestation of endocrine diseases

Front Endocrinol (Lausanne). 2023 Mar 3:14:1155638. doi: 10.3389/fendo.2023.1155638. eCollection 2023.


Chorea is a movement disorder involving involuntary movements of muscles of the face, neck, and limbs, usually caused by basal ganglia lesions. As an important part of the presentation of many neurological diseases, chorea is also an unusual manifestation of endocrine diseases and can be challenging to diagnose. Although the most common etiology of chorea is genetic, it is vital to identify acquired or symptomatic chorea, as these are potentially treatable conditions. This review summarizes the latest developments in various endocrine disease-related chorea, which will help clinicians to correctly identify and accurately treat it.

Keywords: basal ganglia; chorea; endocrine; movement disorder; unusual manifestation.

Publication types

  • Case Reports
  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Basal Ganglia
  • Chorea* / diagnosis
  • Chorea* / etiology
  • Chorea* / therapy
  • Endocrine System Diseases* / pathology
  • Humans

Grants and funding

This work was supported by the National Natural Science Foundation of China (81970714), Science and technology innovation leading talent project of Zhejiang ten thousand people plan (2021R52022) and Zhejiang province health innovative talents project (2021-CXRC07-01).